Breadcrumb Nav
Product Gallery 2
Breadcrumb Nav

The Advanced Acne Solution

Maximum-strength treatment for stubborn breakouts.

Best for Persistent or severe acne. Choose this if you have tried other acne treatments and still struggle with breakouts that will not clear.

Made to treat:

Stubborn Acne Resistant Breakouts Clogged Pores Inflammation Skin Texture

40+ Reviews

$69/month

No Hidden Fees

Cancel Anytime

24/7 Support

Free Delivery

Skip or Delay Refills

Breadcrumb Nav
Breadcrumb Nav

The Advanced Acne Solution

Maximum-strength treatment for stubborn breakouts.

$69/month

Best for Persistent or severe acne. Choose this if you have tried other acne treatments and still struggle with breakouts that will not clear.

Made to treat:

Stubborn Acne Resistant Breakouts Clogged Pores Inflammation

00+ Reviews

No Hidden Fees

Cancel Anytime

24/7 Support

Free Delivery

Skip or Delay Refills

For acne that has not responded to other treatments

Multi-mechanism prescription formula

Targets resistant and inflammatory breakouts

Designed for higher-severity cases

This solution may be ideal for people whose skin is

  • Prone to persistent or severe breakouts that have not improved with other treatments

  • Dealing with both inflammatory and non-inflammatory acne at the same time

  • Producing excess oil that contributes to frequent congestion

  • Able to tolerate a stronger prescription formula, as assessed by a prescriber

A licensed prescriber will determine whether it is appropriate for you. Compounded medications are not FDA approved.

Who it’s For

Refine may be ideal for people whose skin is

  • Prone to persistent or severe breakouts that have not improved with other treatments

  • Dealing with both inflammatory and non-inflammatory acne at the same time

  • Producing excess oil that contributes to frequent congestion

  • Able to tolerate a stronger prescription formula, as assessed by a prescriber

A licensed prescriber will determine whether it is appropriate for you. Compounded medications are not FDA approved.

Proven ingredients, personalized prescriptions

Adapalene

A prescription retinoid that unclogs pores and prevents new breakouts from forming at the follicle level.

Benzoyl Peroxide

Kills acne-causing bacteria deep in the pore to reduce active breakouts, especially resistant ones.

Clindamycin Phosphate

An antibiotic that works alongside other actives to reduce bacterial load and inflammation.

Niacinamide

Helps strengthen the skin barrier, reduce redness, and improve tolerance of maximum-strength ingredients.

Results you can see. Confidence you can feel!

I had cystic acne for over a decade. I had been to three different dermatologists with no long-term success. DermClick's advanced formula finally gave me the results I had been chasing.

Rachel B.

After two rounds of other prescriptions that stopped working, this was the only thing that actually cleared my skin. I wish I had found it sooner.

Marcus T.

My acne was affecting my work and my relationships. Within two months on this formula, my skin was the clearest it had been since high school.

Danielle W.

Not sure which

solution is right for you?

Take our 2-minute skin quiz and

we’ll match you to the right formula.

Not sure which solution is right for you?

Take our 2-minute skin quiz and we’ll match you to the right formula.

© Copyright 2025 DermClick. All Rights Reserved.

© Copyright 2025 DermClick.

All Rights Reserved.