Acne · Maximum Strength

The Advanced Acne Solution ^Rx

Name: The Advanced Acne Solution
Brand: DermClick
Price: 89.00 USD

Adapalene · Benzoyl Peroxide · Clindamycin Phosphate · Niacinamide

Clearer skin for the acne that hasn't responded to less.

$44.50/month

Starting with a 2-month supply

Free shipping
Skip or delay refills
HSA/FSA eligible
Ongoing support

Treatment list

The Advanced Acne Solution ingredient texture callouts

The Advanced Acne Solution benefits for resistant and inflammatory breakouts

Applying The Advanced Acne Solution to persistent acne

Acne · Maximum Strength

The Advanced Acne Solution ^Rx

Adapalene · Benzoyl Peroxide · Clindamycin Phosphate · Niacinamide

Clearer skin for the acne that hasn't responded to less.

$44.50/month

Starting with a 2-month supply

Four prescription actives that work together to clear clogged pores, calm redness and swelling, and hit the bacteria behind deep breakouts without driving antibiotic resistance.

Built for the acne that drugstore products and first-line prescriptions couldn't touch, and delivered to your door.

Treats the following acne concerns:

Free shipping
Skip or delay refills
HSA/FSA eligible
Ongoing support

Formulations

Advanced

Active ingredients:

Adapalene 0.3%
Benzoyl Peroxide 2.5%
Clindamycin Phosphate 1%
Niacinamide 2%

Exact concentrations are determined by your dermatology provider based on your assessment, your tolerance, and your skin's history.

How & Why It Works

Speeds up skin cell turnover to help clear clogged pores
Reduces the bacteria behind deep, inflamed breakouts, without antibiotic resistance
Calms breakouts that are already red and swollen
Helps keep new breakouts from forming under the surface
Helps fade the look of post-acne marks over time
Supports the skin barrier so treatment stays comfortable
Compounded by a licensed pharmacy for each prescription

As with any maximum-strength prescription, some people notice mild, temporary effects as their skin adjusts to treatment. These are typically short-lived and manageable with simple care steps.

Common adjustment effects can include dryness, peeling, or a temporary increase in breakouts as clogged material works its way to the surface. Applying a moisturizer helps soothe irritation, and most people find their skin settles within the first 2 to 4 weeks. A board-certified dermatologist on our clinical team reviews your case and sets a formulation appropriate for your skin.

How to Use

After cleansing, apply one pump to your fingertips and gently massage onto your face at night, or as directed by the board-certified dermatologist on your clinical team.

Follow with a gentle, hydrating moisturizer to keep your skin comfortable as it adjusts.

Wear a broad-spectrum sunscreen, minimum SPF 30, every morning. Adapalene makes your skin more sensitive to sun, so daily protection isn’t optional.

Most people start noticing a shift between weeks 3 and 6, with visible clearing between weeks 7 and 12
Each bottle is approximately a one-month supply

Pairs Well With

The Advanced Redness Solution

A prescription formula that helps fade the look of post-acne red marks and even out tone.

100% Compounded Online PharmacyPrescription-Only TreatmentsNo Long-Term Commitments

What's The Advanced Acne Solution?

Four prescription actives that work together to clear clogged pores, calm redness and swelling, and hit the bacteria behind deep breakouts without driving antibiotic resistance.

Built for the acne that drugstore products and first-line prescriptions couldn't touch, and delivered to your door.

Treats the following acne concerns:

Free shipping
Skip or delay refills
HSA/FSA eligible
Ongoing support

Formulations

Advanced

Active ingredients:

Adapalene 0.3%
Benzoyl Peroxide 2.5%
Clindamycin Phosphate 1%
Niacinamide 2%

Exact concentrations are determined by your dermatology provider based on your assessment, your tolerance, and your skin's history.

How & Why It Works

Speeds up skin cell turnover to help clear clogged pores
Reduces the bacteria behind deep, inflamed breakouts, without antibiotic resistance
Calms breakouts that are already red and swollen
Helps keep new breakouts from forming under the surface
Helps fade the look of post-acne marks over time
Supports the skin barrier so treatment stays comfortable
Compounded by a licensed pharmacy for each prescription

As with any maximum-strength prescription, some people notice mild, temporary effects as their skin adjusts to treatment. These are typically short-lived and manageable with simple care steps.

How to Use

After cleansing, apply one pump to your fingertips and gently massage onto your face at night, or as directed by the board-certified dermatologist on your clinical team.

Follow with a gentle, hydrating moisturizer to keep your skin comfortable as it adjusts.

Wear a broad-spectrum sunscreen, minimum SPF 30, every morning. Adapalene makes your skin more sensitive to sun, so daily protection isn’t optional.

Most people start noticing a shift between weeks 3 and 6, with visible clearing between weeks 7 and 12
Each bottle is approximately a one-month supply

Pairs Well With

The Advanced Redness Solution

A prescription formula that helps fade the look of post-acne red marks and even out tone.

What our customers are saying.

Rachel's acne before and after using The Advanced Acne Solution

BeforeAfter

No makeup, no touchups

★★★★★

“This worked when my first prescription stopped being enough”

“I'd already tried prescription acne treatment before, and for a while it helped. Then the deeper breakouts started coming back around my cheeks and jaw. I felt like I was doing everything right and still waking up with painful new spots. My DermClick dermatologist moved me to the Advanced Acne Solution. The first few weeks took some patience, but around two months I started seeing fewer new inflamed breakouts. I'm past three months now and my skin is the clearest it's been in years.”

Rachel, 32 · Verified Buyer

Danielle's acne before and after using The Advanced Acne Solution

BeforeAfter

No makeup, no touchups

★★★★★

“The deep breakouts were affecting everything”

“My acne wasn't just little surface pimples. I was getting deep, painful bumps along my jaw and cheeks that would take forever to go away and usually left a mark behind. I'd tried so many products that I honestly wasn't expecting much from another one. After about twelve weeks with the Advanced Acne Solution, the number of deep breakouts has dropped dramatically. I still have marks from older acne, but I'm finally not constantly creating new ones.”

Danielle, 28 · Verified Buyer

Alexis's acne before and after using The Advanced Acne Solution

BeforeAfter

No makeup, no touchups

★★★★★

“I had basically accepted that this was just my skin”

“I've had acne on and off for more than ten years. Some periods were better than others, but it always came back. Over-the-counter routines helped temporarily and my previous prescription eventually seemed to stop doing enough. The Advanced Acne Solution took a little time, but by around the third month my cheeks were much clearer, the inflammation had gone down, and even the clogged areas around my jaw looked better. I wish I'd found something like this sooner.”

Alexis, 35 · Verified Buyer

Tiana's acne before and after using The Advanced Acne Solution

BeforeAfter

No makeup, no touchups

★★★★★

“My cheeks don't hurt anymore”

“The worst part of my acne was how inflamed it felt. I would get several red, tender breakouts at the same time, especially across my cheeks. Covering them with makeup usually made the texture look worse. I've been using the Advanced Acne Solution for a little over three months. I now get far fewer inflamed breakouts, and when I look at my before photos, I can't believe how much calmer my skin looks. I still have some marks to work on, but stopping the constant cycle of new acne has been huge for me.”

Tiana, 26 · Verified Buyer

Nicole's acne before and after using The Advanced Acne Solution

BeforeAfter

No makeup, no touchups

★★★★★

“Adult acne that wouldn't respond to anything else”

“My acne became much worse in my late 30s, especially around my chin and jawline. I had clogged pores mixed with larger inflamed breakouts, so treating one problem never seemed to fix the other. After trying multiple routines without lasting improvement, I moved to the Advanced Acne Solution. Around weeks eight to ten I started noticing fewer new breakouts, and by month four my skin looked completely different from where I started. It's not perfect skin, but it's finally manageable skin.”

Nicole, 39 · Verified Buyer

Kayla's acne before and after using The Advanced Acne Solution

BeforeAfter

No makeup, no touchups

★★★★★

“The first thing that made a real difference in my stubborn acne”

“I had already tried drugstore acne products, expensive skincare and a prescription that helped for a while but never completely cleared my skin. I was still getting clusters of breakouts across my cheeks and forehead every month. The Advanced Acne Solution wasn't an overnight fix, but I started noticing a real difference after several weeks. By three months, the number of active breakouts was way down, my pores looked less clogged and my skin felt much calmer. Seeing my before and after photos made me realize how far it had actually come.”

Kayla, 23 · Verified Buyer

The clinical team

The medicine behind your prescription is built by the doctors you already follow.

The Advanced Acne Solution^Rx wasn't formulated by an algorithm or pulled from a generic template. Its protocol was designed by Dr. Lindsey Zubritsky, Dr. Mamina Turegano, and Dr. Jenny Liu — three board-certified dermatologists with combined decades of clinical experience treating real patients. Your prescription is then written by a board-certified dermatologist on our clinical team, working from the protocol they built. Dermatologist-built medicine, delivered to your door.

Dr. Lindsey Zubritsky MDDr. Mamina Turegano, MDDr. Jenny Liu, MD

What's in the bottle

Real actives. Named, not hidden.

The Advanced Acne Solution^Rx pairs four actives — two prescription-strength, two supporting — designed to clear what hasn't cleared before, while keeping your barrier intact through the process.

Active Ingredients

Adapalene

THE CORRECTOR

A prescription-strength retinoid. Supports clogged-looking pores, helps with oiliness, and supports breakouts that may be forming under the surface — the ones you can't see yet.

Clindamycin Phosphate

THE TARGETED ANTIBIOTIC

A topical antibiotic that calms the bacteria driving active, inflamed breakouts. Works on what's already on your face, while adapalene works on what's coming.

Benzoyl Peroxide

THE BACTERIA KILLER

A common topical used in acne-prone routines where C. acnes bacteria may contribute to inflamed or deep breakouts. Works without antibiotic resistance, even after months of consistent use.

Niacinamide

THE BUFFER

A form of vitamin B3 that reduces redness, supports your skin barrier, and makes prescription actives more tolerable. The reason most people quit retinoids is irritation. This is the reason you won't.

Supporting Ingredients

Centella Asiatica

THE CALMER

A clinically studied botanical that soothes irritation and supports recovery. Used in dermatology for decades. The quiet ingredient that keeps the loud ones comfortable.

Ceramides

THE BARRIER REPAIR

Lipids that reinforce the skin barrier and lock in moisture. With maximum-strength actives, barrier health is the limiting factor in how long you can stay on treatment. Ceramides protect the foundation.

Exact concentrations are determined by your dermatology provider based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.

What to expect

A nightly reset for skin that hasn't responded to less.

Applying acne treatment to acne-prone skin

The Advanced Acne Solution^Rx works while you sleep. Prescription-strength adapalene supports clogged pores at depth and helps keep new breakouts from forming under the surface. Benzoyl peroxide supports acne-prone skin where C. acnes bacteria may contribute to inflamed or deep breakouts — and works without antibiotic resistance even after months of consistent use. Clindamycin phosphate supports inflamed-looking breakouts on the surface. Niacinamide keeps your barrier comfortable while the actives do their work.

Supports stubborn, recurring, and deep breakouts
Works alongside acne-prone skin where bacteria may contribute to inflamed breakouts
Reduces clogged pores and oiliness
Smooths post-acne texture
Fades post-acne marks over time
Built for skin that's already been through the prescription learning curve

Built for the woman whose acne hasn't responded to the usual playbook.

The Advanced Acne Solution^Rx is our maximum-strength prescription acne treatment. That means it's formulated for the breakouts that have outlasted over-the-counter routines, first-line prescriptions, and most of what's on your shelf — and it's calibrated by a board-certified dermatologist on your care team so it's strong enough to do the work without wrecking your barrier.

Ideal for you if you're

Dealing with stubborn acne-prone skin — including deep or recurring breakouts that come back even after months of consistent care
Already been on a first-line acne prescription or antibiotic and stopped seeing results
Watching post-acne marks pile up faster than they fade
Considering Accutane but not ready for that step, and want to exhaust the topical route first
Familiar with prescription retinoids and able to tolerate a higher-strength formulation, as confirmed during your assessment

Consider a different fit if you're:

New to prescription retinoids — The Acne Solution^Rx (Core) is the better starting point and steps up cleanly if needed
Pregnant, nursing, or trying to conceive — adapalene and several other actives in this formula aren't appropriate; your assessment will route you to a safer option
Primarily concerned about fine lines or signs of aging — The Acne Solution is built for that
Mostly dealing with persistent redness or rosacea flushing — The Redness Control Formula is built for that
Already on isotretinoin (Accutane), or finished a course within the past 6 months — we'll need to space your treatment appropriately

Realistic timeline

What you may see in 6–12 weeks.

Maximum-strength acne treatment isn't a one-week fix — and the stubborn breakouts you've been chasing took longer than a week to take hold. Real results take time. They also hold.
Here's what most people experience.

Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.

Smiling woman touching her neck after a skincare routine

Weeks 1–2

Adjustment

Your skin gets used to the prescription. Mild dryness, peeling, or a temporary increase in breakouts is common as clogged pores work their way to the surface. With Advanced-tier actives, the adjustment can feel sharper than a Core-tier ramp-up. This is the medication doing its job.

Weeks 3–6

Calming

Active breakouts may start to slow. Visible irritation looks calmer. Deep flares may come less often and resolve faster. Your skin's texture begins to even out. This is the point most people feel the shift.

Weeks 7–12

Visible clearing

Fewer new breakouts. Pores look smaller. Post-acne marks begin to fade. Your skin starts to look like a calmer, clearer version of itself — including the spots that didn't budge on previous treatments.

Beyond 12 weeks

Maintenance and adjustment

Your DermClick care team checks in. If your skin has plateaued or needs more support, your formula is adjusted. This is where most acne treatments fall apart — and where we're built differently.

Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.

How DermClick works

Three steps. No appointments. Reviewed by a board-certified dermatologist within one business day.

Tell us about your skin.

Take our skin assessment. Share your concerns, your skin's history, what you've tried before, and a few photos. The more we know, the better the formula.

Close-up of uneven tone and pigmentation

One business day review

Your case is reviewed within one business day, and your prescription is written by a board-certified dermatologist on our clinical team.

DermClick dermatologist reviewing a formula on a laptop

Adapalene

Clindamycin Phosphate

Benzoyl Peroxide

Niacinamide

Your prescription arrives

Your formula is compounded by a licensed pharmacy and shipped to your door — usually within a week. Your DermClick care team stays with you, adjusting your formula as your skin responds.

DermClick prescription bottle and box inside a delivery package

See the full process →

Frequently Asked Questions

Should I start with The Acne Solutionᴿˣ or step up to The Advanced Acne Solutionᴿˣ?

The Acne Solutionᴿˣ is our Core-tier acne treatment, built for mild to moderate breakouts and for people who haven't been on a prescription retinoid before. The Advanced Acne Solutionᴿˣ is the maximum-strength tier — it keeps the prescription retinoid (adapalene) from the Core formula and adds benzoyl peroxide, formulated for stubborn acne-prone skin with deep or recurring breakouts that haven't responded to over-the-counter or first-line prescription care. If you're not sure, take the assessment. A board-certified dermatologist on your care team will tell you which one matches where your skin actually is — not where you think it should be.

Will I get "the purge" with this?

Possibly, and at Advanced tier it can be more pronounced than with Core. Adapalene accelerates cell turnover, which can push clogged material to the surface before it clears. Benzoyl peroxide adds antibacterial activity that can also temporarily intensify what's coming to the surface. This isn't the prescription making things worse — it's the prescription doing its job. Most people get through the first 2 to 4 weeks and come out the other side with clearer skin than they've had in years. The niacinamide and Centella asiatica in the formula are included specifically to keep this phase manageable. If it gets uncomfortable, message us and we'll adjust your ramp-up.

Can I use this with my current skincare routine, or do I have to start over?

Most of your routine can stay. Gentle cleansers, fragrance-free moisturizers, and broad-spectrum SPF all pair well with The Advanced Acne Solutionᴿˣ. What you need to pause: other topical retinoids (additional adapalene, tretinoin, tazarotene, retinol), high-concentration acids (salicylic, glycolic, lactic), and any other benzoyl peroxide products — doubling up increases irritation without improving results. A board-certified dermatologist on your care team will review your current products during your assessment and tell you exactly what to keep, drop, and add.

Is The Advanced Acne Solutionᴿˣ safe with pregnancy, nursing, or other medications?

The assessment specifically asks. Tretinoin and several other actives in this formula aren't appropriate during pregnancy or nursing. If any of these apply to you, a board-certified dermatologist on your care team will route you to a safer alternative. If we can't safely prescribe for you, we'll tell you before charging you. We don't write prescriptions that shouldn't be written.

When will I see results?

Most people start noticing a real shift between weeks 4 and 8 with consistent nightly use. Weeks 1–2 are the adjustment period — expect some dryness and possibly a temporary increase in breakouts as clogged pores surface. Weeks 3–6, deep flares may come less often and visible irritation may look calmer. Weeks 6–12, fewer new breakouts, smaller-looking pores, and post-acne marks begin to fade. The breakouts you've been chasing for years don't disappear in a week — but the right prescription can still help support clearer-looking skin.

What type of skin is The Advanced Acne Solutionᴿˣ designed for?

It's designed for moderate to severe acne-prone skin — specifically the kind that's already been through OTC actives, first-line prescriptions, and antibiotics without getting lasting results. It's formulated for skin that's familiar with prescription retinoids and ready for a higher-strength combination. It's not the right starting point for someone new to prescription treatment — The Acne Solutionᴿˣ (Core) is built for that, and steps up cleanly to this formula if needed.

Where can I find full safety information?

Full prescribing details, including side effects, drug interactions, and who shouldn't use this treatment, are available on our Important Safety Information page. We recommend reading it before starting treatment.

The Advanced Acne Solution^Rx is our maximum-strength prescription formula for stubborn acne-prone skin with deep or recurring breakouts. If your skin needs something gentler — or you're new to prescription retinoids — there's a tier built for that. Your assessment routes you to the one that fits.

Core